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BioXcell熱銷產(chǎn)品InVivoMab anti-mouse CD28/小鼠CD28單克隆抗體

更新時間：2023-07-05   點擊次數(shù)：403次

BioXcell熱銷產(chǎn)品InVivoMab anti-mouse CD28/小鼠CD28單克隆抗體


產(chǎn)品描述：


The 37.51 monoclonal antibody reacts with mouse CD28, a 45 kDa costimulatory receptor and a member of the Ig superfamily. CD28 is expressed by thymocytes, most peripheral T cells, and NK cells. CD28 is a receptor for CD80 (B7-1) and CD86 (B7-2). Signaling through CD28 augments IL-2 and IL-2 receptor expression as well as cytotoxicity of CD3-activated T cells. The 37.51 antibody has been shown to stimulate the proliferation and cytokine production by activated T and NK cells and provide a costimulatory signal for CTL induction.


BioXcell InVivoMab anti-mouse CD28 37.51單克隆抗體與小鼠CD28反應，CD28是一種45kDa的共刺激受體，也是Ig超家族的一員。CD28由胸腺細胞，大多數(shù)外周T細胞和NK細胞表達。CD28是CD80（B7-1）和CD86（B7-2）的受體。通過CD28的信號傳導增強了IL-2和IL-2受體的表達以及CD3活化的T細胞的細胞毒性。37.51抗體已被證明能刺激活化的T細胞和NK細胞的增殖和細胞因子的產(chǎn)生，并為CTL誘導提供共刺激信號。

BioXcell熱銷產(chǎn)品--InVivoMab anti-mouse CD28 


產(chǎn)品詳情：

產(chǎn)品名稱

InVivoMAb anti-mouse CD28

產(chǎn)品貨號

BE0015-1

產(chǎn)品規(guī)格

1/5/25/50/100mg

反應種屬

Mouse

克隆號

37.51

同種型

Syrian Hamster IgG2

免疫原

C57BL/6 mouse T cell lymphoma EL-4 cells

實驗應用

in vitro T cell stimulation/activation

in vivo CD28 blockade

產(chǎn)品形式

PBS, pH 6.0 0.01% Tween,Contains no stabilizers or preservatives

純度

>95%, Determined by SDS-PAGE

無菌處理

0.2 µm filtration

純化方式

Protein G

RRID

AB_1107624

分子量

150 kDa

保存條件

抗體原液保存在4°C，不能冷凍保存。

推薦同型對照

InVivoMAb polyclonal Syrian hamster IgG（貨號BE0087）

推薦抗體稀釋液

InVivoPure pH 6.0T Dilution Buffer（貨號IPT060）

 

 該產(chǎn)品自上市已被多篇SCI文獻引用，品質(zhì)有保證，以下是部分已發(fā)表的文獻引用：


應用

文章

體外T細胞刺激/激活

(in vitro T cell stimulation/activation)

1. Lacher, S. M., et al. (2018). 'NF-kappaB inducing kinase (NIK) is an essential post-transcriptional regulator of T-cell activation affecting F-actin dynamics and TCR signaling' J Autoimmun 94: 110-121.

2. Wendland, K., et al. (2018). 'Retinoic Acid Signaling in Thymic Epithelial Cells Regulates Thymopoiesis' J Immunol 201(2): 524-532.

3. Ron-Harel, N., et al. (2016). 'Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation' Cell Metab 24(1): 104-117.

4. Gu, A. D., et al. (2015). 'A critical role for transcription factor Smad4 in T cell function that is independent of transforming growth factor beta receptor signaling' Immunity 42(1): 68-79.

5. Choi, Y. S., et al. (2015). 'LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6' Nat Immunol 16(9): 980-990.  

體內(nèi)CD28阻斷

(in vivo CD28 blockade)

1. Rouhani, S. J., et al. (2015). 'Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction' Nat Commun 6: 6771.

2. Eberlein, J., et al. (2012). 'Multiple layers of CD80/86-dependent costimulatory activity regulate primary, memory, and secondary lymphocytic choriomeningitis virus-specific T cell immunity' J Virol 86(4): 1955-1970.

 

 

BioXcell熱銷產(chǎn)品--InVivoMab anti-mouse CD28


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